edited by Marta Bertolaso, Miles MacLeod

Undoubtedly, the future of biology is as a technoscience, in which technical and engineering expertise are as important as biological knowledge and experimental skill. But what can we really expect from technology? How effective will it be and what impact will it have on biological knowledge? How will the role of scientists as human beings be transformed by this epochal transformation? How autonomous will the role of technology be with respect to human contributions in driving research? In this Special Issue we try to lay some foundations for answering these questions by focusing on in silico models.